Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hnf4a  hepatic nuclear factor 4, alpha   (Synonyms: Hnf4, HNF-4, HNF4 alpha, MODY1, Nr2a1, Nuclear receptor 2A1, Tcf14, Tcf4)
Results	Reference
1	J:150973 Antoniou A, Raynaud P, Cordi S, Zong Y, Tronche F, Stanger BZ, Jacquemin P, Pierreux CE, Clotman F, Lemaigre FP, Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Gastroenterology. 2009 Jun;136(7):2325-33
1	J:263981 Benhamouche-Trouillet S, O'Loughlin E, Liu CH, Polacheck W, Fitamant J, McKee M, El-Bardeesy N, Chen CS, McClatchey AI, Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis. Development. 2018 Apr 30;145(9):dev162123
1*	J:284137 Chen L, Toke NH, Luo S, Vasoya RP, Aita R, Parthasarathy A, Tsai YH, Spence JR, Verzi MP, HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine. Development. 2019 Aug 6;146(19):dev179432
1	J:287010 Deacon P, Concodora CW, Chung E, Park JS, beta-catenin regulates the formation of multiple nephron segments in the mouse kidney. Sci Rep. 2019 Nov 4;9(1):15915
1	J:262635 Drake KA, Adam M, Mahoney R, Potter SS, Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney. Sci Rep. 2018 Apr 20;8(1):6306
1	J:168727 Furuyama K, Kawaguchi Y, Akiyama H, Horiguchi M, Kodama S, Kuhara T, Hosokawa S, Elbahrawy A, Soeda T, Koizumi M, Masui T, Kawaguchi M, Takaori K, Doi R, Nishi E, Kakinoki R, Deng JM, Behringer RR, Nakamura T, Uemoto S, Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet. 2011 Jan;43(1):34-41
1*	J:124920 Garrison WD, Battle MA, Yang C, Kaestner KH, Sladek FM, Duncan SA, Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology. 2006 Apr;130(4):1207-20
1	J:166890 Hofmann JJ, Zovein AC, Koh H, Radtke F, Weinmaster G, Iruela-Arispe ML, Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development. 2010 Dec;137(23):4061-72
1*	J:124126 Hunter MP, Wilson CM, Jiang X, Cong R, Vasavada H, Kaestner KH, Bogue CW, The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis. Dev Biol. 2007 Aug 15;308(2):355-67
1*	J:192058 Jonckheere N, Vincent A, Franquet-Ansart H, Witte-Bouma J, Korteland-van Male A, Leteurtre E, Renes IB, Van Seuningen I, GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells. Biochim Biophys Acta. 2012 Aug;1819(8):869-76
1	J:299297 Just PA, Poncy A, Charawi S, Dahmani R, Traore M, Dumontet T, Drouet V, Dumont F, Gilgenkrantz H, Colnot S, Terris B, Coulouarn C, Lemaigre F, Perret C, LKB1 and Notch Pathways Interact and Control Biliary Morphogenesis. PLoS One. 2015;10(12):e0145400
1	J:199204 Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M, Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice. Hepatology. 2013 Jun;57(6):2502-13
1	J:111670 Kyrmizi I, Hatzis P, Katrakili N, Tronche F, Gonzalez FJ, Talianidis I, Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 2006 Aug 15;20(16):2293-305
1*	J:140018 Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, Duncan SA, Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology. 2008 Oct;48(4):1242-50
1*	J:263032 Magella B, Mahoney R, Adam M, Potter SS, Reduced Abd-B Hox function during kidney development results in lineage infidelity. Dev Biol. 2018 Jun 15;438(2):84-93
1	J:266356 Marable SS, Chung E, Adam M, Potter SS, Park JS, Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome. JCI Insight. 2018 Jul 25;3(14)
1	J:261627 Mori K, Nakamura H, Kurooka H, Miyachi H, Tamada K, Sugai M, Takumi T, Yokota Y, Id2 determines intestinal identity through repression of the foregut transcription factor, Irx5. Mol Cell Biol. 2018 Feb 20;
1	J:161574 Onitsuka I, Tanaka M, Miyajima A, Characterization and functional analyses of hepatic mesothelial cells in mouse liver development. Gastroenterology. 2010 Apr;138(4):1525-35, 1535.e1-6
1	J:224392 Poncy A, Antoniou A, Cordi S, Pierreux CE, Jacquemin P, Lemaigre FP, Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts. Dev Biol. 2015 Aug 15;404(2):136-48
1	J:241275 Reginensi A, Enderle L, Gregorieff A, Johnson RL, Wrana JL, McNeill H, A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nat Commun. 2016 Aug 02;7:12309
1	J:333939 Saisa-Borreill S, Davidson G, Kleiber T, Thevenot A, Martin E, Mondot S, Blottiere H, Helleux A, Mengus G, Plateroti M, Duluc I, Davidson I, Freund JN, General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions. Cell Death Differ. 2023 Mar;30(3):839-853
1	J:208341 Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B, Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
1	J:138818 Tatarakis A, Margaritis T, Martinez-Jimenez CP, Kouskouti A, Mohan WS 2nd, Haroniti A, Kafetzopoulos D, Tora L, Talianidis I, Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Mol Cell. 2008 Aug 22;31(4):531-43
1	J:174261 Tchorz JS, Kinter J, Muller M, Tornillo L, Heim MH, Bettler B, Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice. Hepatology. 2009 Sep;50(3):871-9
1	J:214986 Walker EM, Thompson CA, Battle MA, GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development. Dev Biol. 2014 Aug 15;392(2):283-94
1	J:218847 Walker EM, Thompson CA, Kohlnhofer BM, Faber ML, Battle MA, Characterization of the developing small intestine in the absence of either GATA4 or GATA6. BMC Res Notes. 2014;7:902
1	J:289492 Yi J, Lu L, Yanger K, Wang W, Sohn BH, Stanger BZ, Zhang M, Martin JF, Ajani JA, Chen J, Lee JS, Song S, Johnson RL, Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Hepatology. 2016 Nov;64(5):1757-1772